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Nerve & Muscle Tissue
What is Histology? (an unconventional introduction)
Histology Topics for Lincoln Scholars Program

Connective tissues of dermis and hypodermis

What is histology?  (For a more formal introduction, click here.)

The discipline of "histology" takes its name from histo, the Greek word for "web."  This discipline focuses on the tissue level of anatomical organization.

Histology is quite closely related to "microscopic anatomy," and microscopes have indeed become iconic tools for observing tissues.  Nevertheless, it is possible to study elaborate microscopic details in the lung, say, or the kidney, without ever appreciating the fundamental tissue organization of each structure's various parts.  In contrast, a tissue-level perspective can clarify underlying patterns -- for example, that both the lung and the kidney share with pancreas a basic pattern of glandular tissue architecture.  Or that inflammation can follow the same tissue pathway into many seemingly different organs.

Histology is also closely related to cell biology.  But modern cell biology has more in common with biochemistry and molecular biology than with the tissue composition of organs.  Cell biology looks inward, into the component parts of individual cells.  One can learn a great deal about cells without ever appreciating how cells are arranged into the common set of patterns that underlie the tissue-scale architecture of glands and other organs. 

That a tissue-level perspective could contribute to an understanding of pathological processes such as inflammation was demonstrated by Xavier Bichat (the "father of histology"), several decades before establishment of Cell Theory.  This perspective helped nineteenth-century physicians understand and organize the tremendous wealth of anatomical detail that was being revealed by the burgeoning field of microscopy.  Contemporary appreciation for histology's value in medicine was nicely captured by George Elliot in her 1871 historical novel Middlemarch:

"That great Frenchman [i.e., Bichat] first carried out the conception that living bodies ... must be regarded as consisting of certain primary webs or tissues, out of which the various organs ... are compacted, as the various accommodations of a house are built up in various proportions of wood, iron, stone, brick, zinc, and the rest...  And the conception wrought out by Bichat, with his detailed study of the different tissues, acted necessarily on medical questions as the turning of gas-light would act on a dim, oil-lit street, showing new connections and hitherto hidden facts of structure which must be taken into account in considering the symptoms of maladies and the action of medicaments."

Bichat described 21 "simple tissues."  Modern histology has condensed this list into four basic tissue types.  These are epithelial tissue, connective tissue, muscle tissue, and nervous tissue.  The concept of "four basic tissue types" provides a powerful framework for organizing a great wealth of anatomical and functional detail. 

Each of the four basic tissue types has its own characteristic pattern of organization.  Yet within each of these basic patterns there are several distinctive varieties:

Esophageal mucosa

The basic tissue types can sometimes be readily distinguished from one another, as displayed by tissue layers in the image at right.  However, the basic tissue types can also present with a variety of appearances that are not so visually obvious, calling for more subtle interpretation.  This is especially true when three-dimensional tissue configurations are sliced and viewed in various planes of section on a microscope slide. 

Several varieties of tissue are quite widely distributed throughout the body.  Each of the examples in the list below has its own distinctive microscopic appearance, which should eventually become familiar in the context of various organs:

Additional special varieties of the four basic tissue types occur in a more limited number of locations and can be learned as occasion arises.  These include, among others, bone, cartilage, skeletal and cardiac muscle, urothelium (or transitional epithelium), peripheral ganglia, central nervous tissue, lymphoid tissue, and simple squamous epithelium (including mesothelium and endothelium).

For a much longer and more formal introduction to histology, see this page.

Histology Topics for Lincoln Scholars Program

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Comments and questions:

SIUC / School of Medicine / Anatomy / David King
Last updated:  4 August 2022 / dgk